A metabolic perspective to sleep genetics

The metabolic signals that regulate sleep and the metabolic functions that occur during sleep are active areas of research. Prior studies have focused on sugars and nucleotides but new genetic evidence suggests novel functions of lipid and amino acid metabolites in sleep. Additional genetic studies of energetic signaling pathways and the circadian clock transcription factor network have increased our understanding of how sleep responds to changes in the metabolic state. This review focuses on key recent insights from genetic experiments in humans and model organisms to improve our understanding of the interrelationship between metabolism and sleep. •Genetic identification of metabolic signaling pathways in sleep.•Genetic insight into neuropeptides with dual roles in sleep and feeding.•Circadian rhythms are at the intersection of metabolism and sleep.