Chromatographic Methods for the Analysis of the Antipsychotic Drug Clozapine and Its Major Metabolites: A Review

Chromatographic Methods for the Analysis of the Antipsychotic Drug Clozapine and Its Major Metabolites: A Review

Clozapine (CLZ), a second-generation antipsychotic, can effectively reduce schizophrenia, bipolar disorder and major depression symptoms. This review provides an overview of all reported chromatographic methods (62 references) for the quantification of CLZ and its two main metabolites, norclozapine...

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Veröffentlicht in:Journal of chromatographic science 2024-04
Hauptverfasser: Hrichi, Hajer, Kouki, Noura, Elkanzi, Nadia Ali Ahmed
Format: Artikel
Sprache:eng
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Zusammenfassung:Clozapine (CLZ), a second-generation antipsychotic, can effectively reduce schizophrenia, bipolar disorder and major depression symptoms. This review provides an overview of all reported chromatographic methods (62 references) for the quantification of CLZ and its two main metabolites, norclozapine and clozapine N-oxide in pharmaceutical formulations, biological matrices and environmental samples.
ISSN:0021-9665
1945-239X
DOI:10.1093/chromsci/bmae016