Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn’s Disease and Ulcerative Colitis

Background Patient-reported outcomes (PROs), such as the short CD activity index (sCDAI) and partial Mayo Score (PMS), are used to define clinical remission in IBD, but may not represent the true degree of inflammation and endoscopy is invasive. Non-invasive testing options include c-reactive protei...

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Veröffentlicht in:Digestive diseases and sciences 2024-06, Vol.69 (6), p.2154-2163
Hauptverfasser: Motwani, Kiran K., Alizadeh, Madeline, Abutaleb, Ameer, Grossman, Jennifer, Wellington, Jennifer, Cross, Raymond K.
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Sprache:eng
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Zusammenfassung:Background Patient-reported outcomes (PROs), such as the short CD activity index (sCDAI) and partial Mayo Score (PMS), are used to define clinical remission in IBD, but may not represent the true degree of inflammation and endoscopy is invasive. Non-invasive testing options include c-reactive protein (CRP) and fecal calprotectin (FCP). Aim The aim of this study was to assess the degree of correlation of non-invasive biomarkers with PROs and the impact other clinical variables can have on their levels. Methods We reviewed data collected from the prospective cohort, Study of a Prospective Adult Research Cohort with IBD (SPARC-IBD), comprised of over 3000 patients from 17 tertiary referral centers. Demographic and clinical variables were analyzed by disease type, disease severity was based on PROs, and baseline CRP and FCP were measured. For comparative analysis, we performed Fisher’s exact test and Welch’s t test, where p  
ISSN:0163-2116
1573-2568
1573-2568
DOI:10.1007/s10620-024-08421-w