Novel antivirals for severe enterovirus infection in immunocompromised hosts; A case series

Novel antivirals for severe enterovirus infection in immunocompromised hosts; A case series

•Enteroviruses can cause significant morbidity and mortality in immunocompromised.•Serial tests in multiple compartments may be necessary to identify Enterovirus.•Metagenomics on brain biopsy may be justified when conventional testing is negative.•Early combination antiviral treatments can improve o...

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Veröffentlicht in:The Journal of infection 2024-05, Vol.88 (5), p.106142-106142, Article 106142
Hauptverfasser: Meinhardt, Andrea, Reilly, Liam, Kaliakatsos, Marios, Abdel-Aziz, Khaled, Alsharidah, Sondus, Bodi, Istvan, Booth, Claire, Chetty, Kritika, Evans, Jennifer, Ferreras-Antolín, Laura, Froude, Susannah, Galtrey, Clare M., Guruprasad, Suba, Hadden, Robert D., Hassell, Jane, Hyöty, Heikki, Kreins, Alexandra Y., Laiho, Jutta E., Lowe, David M., Lunn, Michael P., Mankad, Kshitij, Struik, Siske, Whittaker, Elizabeth, Worth, Austen, Yong, Patrick, Zhang, Liqun, Breuer, Judith, Kadambari, Seilesh
Format: Artikel
Sprache:eng
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Zusammenfassung:•Enteroviruses can cause significant morbidity and mortality in immunocompromised.•Serial tests in multiple compartments may be necessary to identify Enterovirus.•Metagenomics on brain biopsy may be justified when conventional testing is negative.•Early combination antiviral treatments can improve outcomes in immunocompromised.•Antiviral therapy acts as bridging therapy until immune reconstitution.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2024.106142