Copper catalysed asymmetric amination

Copper catalysed asymmetric amination

Chiral amines possessing a stereogenic carbon atom bearing three carbon substituents and one nitrogen substituent are challenging structural motifs to prepare enantioselectively. Now, such motifs have been accessed in high enantiopurities by asymmetric Cu-catalysed propargylic amination using steric...

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Veröffentlicht in:Nature chemistry 2024-04, Vol.16 (4), p.483-484
1. Verfasser: Sieber, Joshua D.
Format: Artikel
Sprache:eng
Schlagworte:
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639/638/77/883
Amination
Amines
Analytical Chemistry
Asymmetry
Biochemistry
Carbon
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Copper
Inorganic Chemistry
Ligands
News & Views
news-and-views
Nitrogen
Organic Chemistry
Physical Chemistry
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Beschreibung
Zusammenfassung:Chiral amines possessing a stereogenic carbon atom bearing three carbon substituents and one nitrogen substituent are challenging structural motifs to prepare enantioselectively. Now, such motifs have been accessed in high enantiopurities by asymmetric Cu-catalysed propargylic amination using sterically confined ligands.
ISSN:1755-4330
1755-4349
DOI:10.1038/s41557-024-01487-z