The Hepatocurative Effects of Zanthoxylum zanthoxyloides Alkaloids on Tetrachloromethane-Induced Hepatotoxicity on Albino Rats

The study investigated the hepatocurative activity of the bulk alkaloids of Zanthoxylum zanthoxyloides in a tetrachloromethane (CCl 4 )-induced hepatotoxicity model in rats. The hepatocurative activity of the alkaloids at 200, 400 and 600 mg/kg doses was demonstrated by the assay of both enzymic and...

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Veröffentlicht in:	Indian journal of clinical biochemistry 2024-04, Vol.39 (2), p.188-196
Hauptverfasser:	Ayoka, Thecla Okeahunwa, Nwachukwu, Ngwu, Ene, Aloysius Chinedu, Igwe, Chidi Uzoma, Nnadi, Charles Okeke
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Ascorbic acid Bilirubin Biochemistry Biomedical and Life Sciences Butylated hydroxytoluene Carbon tetrachloride Chemistry/Food Science Hepatotoxicity High density lipoprotein Life Sciences Liver Low density lipoprotein Microbiology Original Research Article Pathology Zanthoxylum zanthoxyloides
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Zusammenfassung:	The study investigated the hepatocurative activity of the bulk alkaloids of Zanthoxylum zanthoxyloides in a tetrachloromethane (CCl 4 )-induced hepatotoxicity model in rats. The hepatocurative activity of the alkaloids at 200, 400 and 600 mg/kg doses was demonstrated by the assay of both enzymic and non-enzymic parameters. Sections of the liver were also subjected to histological examinations. Mapping techniques and data visualization approaches were adopted in finding relationships between the enzymic and non-enzymic parameters and the treatment groups. The bulk alkaloids caused dose-dependent effects on both the enzymic and non-enzymic parameters. The bulk alkaloids elicited a significant reduction ( p
ISSN:	0970-1915 0974-0422
DOI:	10.1007/s12291-022-01095-z