A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss

A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss

Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-analysis of genome-wide association studies, researchers identified a genetic variant that seems to increase risk of pregnancy loss by dysregulating meiotic recombination between...

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Veröffentlicht in:Nature structural & molecular biology 2024-04, Vol.31 (4), p.584-585
Hauptverfasser: Carioscia, Sara A., McCoy, Rajiv C.
Format: Artikel
Sprache:eng
Schlagworte:
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Biobanks
Biochemistry
Biological Microscopy
Biomedical and Life Sciences
Chromosomes
Genetic diversity
Genetic factors
Genetic testing
Genetic variance
Genome-wide association studies
Genomes
Homologous recombination
Hypotheses
In vitro fertilization
Life Sciences
Meiosis
Membrane Biology
Molecular biology
News & Views
news-and-views
Pregnancy
Protein Structure
Proteins
Scholarships & fellowships
Statistical power
Yeast
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Beschreibung
Zusammenfassung:Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-analysis of genome-wide association studies, researchers identified a genetic variant that seems to increase risk of pregnancy loss by dysregulating meiotic recombination between homologous chromosomes during egg formation.
ISSN:1545-9993
1545-9985
1545-9985
DOI:10.1038/s41594-024-01269-8