Development and validation of a GC–MS/MS method for the determination of iodoacetic acid in biological samples

Iodoacetic acid (IAA) is a halogenated disinfection by-product of growing concern due to its high cytotoxicity, genotoxicity, endocrine disruptor effects, and potential carcinogenicity. However, the data on distribution and excretion of IAA after ingestion by mammals are still scarce. Here, we devel...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2024-05, Vol.416 (13), p.3185-3194
Hauptverfasser:	Yu, Hanning, Wu, Linying, Xuan, Dongliang, Peng, Qian, Qu, Weidong, Zhou, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Agricultural commodities Analytical Chemistry Animals Biochemistry Biocompatibility Biological properties Biological samples byproducts Carcinogenicity Carcinogens Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography Cytotoxicity detection limit digestive tract Disease control disinfection Disinfection & disinfectants Drinking water endocrine-disrupting chemicals Excretion Feces Feces - chemistry Food Science Gas chromatography Gas Chromatography-Mass Spectrometry - methods Gastrointestinal system Gastrointestinal tract Genotoxicity Health care In vivo methods and tests Ingestion Iodoacetic Acid Kidney - chemistry Kidney - metabolism Kidneys Laboratory animals Laboratory Medicine Limit of Detection Liver Liver - chemistry Liver - metabolism Male Mammals Mass spectrometry Mass spectroscopy Metabolism Monitoring/Environmental Analysis oral exposure Organic chemicals Plasma Public health Quadrupoles Rats Rats, Sprague-Dawley Reproducibility of Results Research Paper Sample preparation Scientific imaging spleen Tandem Mass Spectrometry - methods Thyroid Thyroid gland Tissue Distribution Urine
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Zusammenfassung:	Iodoacetic acid (IAA) is a halogenated disinfection by-product of growing concern due to its high cytotoxicity, genotoxicity, endocrine disruptor effects, and potential carcinogenicity. However, the data on distribution and excretion of IAA after ingestion by mammals are still scarce. Here, we developed a reliable and validated method for detecting IAA in biological specimens (plasma, urine, feces, liver, kidney, and tissues) based on modified QuEChERS sample preparation combined with gas chromatography-tandem triple quadrupole mass spectrometry (GC–MS/MS). The detection method for IAA exhibited satisfactory recovery rates (62.6–108.0%) with low relative standard deviations (RSD
ISSN:	1618-2642 1618-2650 1618-2650
DOI:	10.1007/s00216-024-05266-0