Biocatalysis of CO2 and CH4: Key enzymes and challenges

Mitigating greenhouse gas emissions is a critical challenge for promoting global sustainability. The utilization of CO2 and CH4 as substrates for the production of valuable products offers a promising avenue for establishing an eco-friendly economy. Biocatalysis, a sustainable process utilizing enzymes to facilitate biochemical reactions, plays a significant role in upcycling greenhouse gases. This review provides a comprehensive overview of the enzymes and associated reactions involved in the biocatalytic conversion of CO2 and CH4. Furthermore, the challenges facing the field are discussed, paving the way for future research directions focused on developing robust enzymes and systems for the efficient fixation of CO2 and CH4. •Enzymes involved in the biocatalysis of CO2 and CH4 are summarized systemically.•Existing challenges in biocatalysis of CO2 and CH4 are pointed out.•Future directions towards robust systems for CO2 and CH4 fixation are proposed.