Syk inhibition suppresses NLRP3 inflammasome activation in platelets from sickle cell mice leading to decreased platelet secretion, aggregation, spreading, and in vitro thrombus formation

•Syk inhibition with R406 decreases NLRP3 inflammasome activation in platelets from sickle cell mice.•R406 inhibits platelet activation and in vitro thrombus formation in sickle cell mice.•The effect of R406 on platelets from sickle cell mice is partially reversed by the NLRP3 activator nigericin.•Injection of R406 into sickle cell mice decreases platelet aggregation and ATP secretion without affecting bleeding time.