Benzophenone-3 alters expression of genes encoding vascularization and epithelial-mesenchymal transition functions during Trp53-null mammary tumorigenesis
Benzophenone-3 (also referred to as oxybenzone) is a putative endocrine disrupting chemical and common ingredient in sunscreens and other personal care products. We previously showed that benzophenone-3 was promotional for epithelial tumorigenesis in mice fed adult high-fat diet, while protective ag...
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Veröffentlicht in: | Food and chemical toxicology 2024-04, Vol.186, p.114540-114540, Article 114540 |
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Sprache: | eng |
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Zusammenfassung: | Benzophenone-3 (also referred to as oxybenzone) is a putative endocrine disrupting chemical and common ingredient in sunscreens and other personal care products. We previously showed that benzophenone-3 was promotional for epithelial tumorigenesis in mice fed adult high-fat diet, while protective against the incidence of more aggressive spindle cell tumors in the same treatment group. In this study, we show that benzophenone-3 reduces epithelial to mesenchymal transition in the epithelial tumors of these mice. This reduction in epithelial to mesenchymal transition is associated with altered expression of several genes involved in regulation of angiogenesis and epithelial to mesenchymal transition. Among the genes altered in expression, Timp1 is of particular interest because benzophenone-3 suppressed both migration and Timp1 expression in a mammary tumor cell line that displays epithelial to mesenchymal transition characteristics. These alterations in gene expression plausibly stabilize the vasculature of epithelial carcinomas and contribute to benzophenone-3 promotion of epithelial tumors, while at the same time suppress epithelial to mesenchymal transition and suppress incidence of spindle cell tumors.
•In mice fed adult high-fat diet, BP-3 reduces Trp53null epithelial tumors with epithelial to mesenchymal transition (EMT).•BP-3 alters expression of several genes involved in regulation of angiogenesis and EMT.•Timp1 is of interest with BP-3 decreased expression in tumors, and decreased migration and expression in an EMT cell line.•BP-3 altered expression may stabilize vasculature of epithelial tumors, while suppressing EMT and spindle cell tumors. |
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ISSN: | 0278-6915 1873-6351 |
DOI: | 10.1016/j.fct.2024.114540 |