Clinical Impacts of Urinary Neutrophil Gelatinase-Associated Lipocalin in Patients With Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention

Background: Chronic kidney disease (CKD) is associated with poor prognosis in patients undergoing percutaneous coronary intervention (PCI). Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for renal injury. However, the association between urinary NGAL concentrations and rena...

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Veröffentlicht in:	Circulation Journal 2024/05/24, Vol.88(6), pp.944-950
Hauptverfasser:	Ozaki, Yuta, Uemura, Yusuke, Tanaka, Akihito, Yamaguchi, Shogo, Okajima, Takashi, Mitsuda, Takayuki, Ishikawa, Shinji, Takemoto, Kenji, Murohara, Toyoaki, Watarai, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomarkers - urine Chronic kidney disease Female Glomerular Filtration Rate Humans Lipocalin-2 - urine Male Middle Aged Neutrophil gelatinase-associated lipocalin Percutaneous coronary intervention Percutaneous Coronary Intervention - adverse effects Prognosis Renal Insufficiency, Chronic - urine Risk Factors
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Zusammenfassung:	Background: Chronic kidney disease (CKD) is associated with poor prognosis in patients undergoing percutaneous coronary intervention (PCI). Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for renal injury. However, the association between urinary NGAL concentrations and renal and cardiovascular events in patients with CKD undergoing PCI has not been elucidated. This study investigated the clinical impact of urinary NGAL concentrations on renal and cardiovascular outcomes in patients with non-dialysis CKD undergoing PCI.Methods and Results: We enrolled 124 patients with non-dialysis CKD (estimated glomerular filtration rate
ISSN:	1346-9843 1347-4820 1347-4820
DOI:	10.1253/circj.CJ-24-0060