Polymeric biocompatible structures for controlled drug release
The purpose of using polymers in drug delivery systems is to be able to create a membrane-like barrier that would control the delivery of the active agent for an extended period. Poly (2-hydroxyethyl methacrylate) (pHEMA), when cross-linked, swells to a significant extent. Hence, it was thought nece...
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Veröffentlicht in: | Journal of Optoelectronics and Advanced Materials 2007-09, Vol.9 (9), p.2917-2920 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The purpose of using polymers in drug delivery systems is to be able to create a membrane-like barrier that would control the delivery of the active agent for an extended period. Poly (2-hydroxyethyl methacrylate) (pHEMA), when cross-linked, swells to a significant extent. Hence, it was thought necessary to determine its degree of swelling when incorporating methyl methacrylate (MMA), which is a hydrophobic monomer. The polymeric micro-beads of p(HEMA) and functionalised biopolymers of p(HEMA-co-MMA), p(HEMA-co-AA) and p(HEMA-co-MMA-co-AA) were prepared by precipitant polymerisation method. There were obtained different types of micro-polymeric beads, which were characterised by elemental analysis, measure of the degree of swelling, scanning electron microscopy (SEM), and in vitro tests. All these tests gave satisfactory results. |
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ISSN: | 1454-4164 |