Coating of Human Mesenchymal Cells in 3D Culture with Bioinorganic Nanoparticles Promotes Osteoblastic Differentiation and Gene Transfection

Coating of Human Mesenchymal Cells in 3D Culture with Bioinorganic Nanoparticles Promotes Osteoblastic Differentiation and Gene Transfection

Mesenchymal cells are modified in suspension with bio‐functionalized calcium phosphate nanoparticles using a scaffold‐free cell decoration method. Coated cells remain viable and retain functionality, with cell activity stimulated by the structure and composition of the coating.

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Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Weinheim) 2007-09, Vol.19 (17), p.2236-2240
Hauptverfasser: Gonzalez-McQuire, R., Green, D. W, Partridge, K. A, Oreffo, R. O. C., Mann, S., Davis, S. A.
Format: Artikel
Sprache:eng
Schlagworte:
Biomaterials
Cells
Nanoparticles
Tissue engineering
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Beschreibung
Zusammenfassung:Mesenchymal cells are modified in suspension with bio‐functionalized calcium phosphate nanoparticles using a scaffold‐free cell decoration method. Coated cells remain viable and retain functionality, with cell activity stimulated by the structure and composition of the coating.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200602770