Assessment of Occupational Exposure of Pharmaceutical Plant Workers to 5-Fluorouracil: Determination of α-Fluoro-β-alanine in Urine

The exposure of pharmaceutical plant workers, involved in drug compounding and drug production, to 5-fluorouracil (5FU) was studied. 5FU was found by the analysis of air and wipe samples. During weighing, 5FU was detected in the air (75 µg/m³). 5FU was also present on the filter of the mask of the w...

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Veröffentlicht in:	Journal of occupational medicine 1994-01, Vol.36 (1), p.79-83
Hauptverfasser:	Sessink, Paul J. M., Timmersmans, Johan L., Anzion, Rob B. M., Bos, Rob P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants, Occupational - adverse effects Air Pollutants, Occupational - pharmacokinetics beta-Alanine - analogs & derivatives beta-Alanine - pharmacokinetics Biological and medical sciences Drug Compounding Drug Industry Drug toxicity and drugs side effects treatment Environmental Monitoring Fluorouracil - adverse effects Fluorouracil - pharmacokinetics Gas Chromatography-Mass Spectrometry Humans Medical sciences Metabolic Clearance Rate - physiology Miscellaneous (drug allergy, mutagens, teratogens...) Occupational Exposure - adverse effects ORIGINAL ARTICLES Pharmacology. Drug treatments Protective Clothing
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Zusammenfassung:	The exposure of pharmaceutical plant workers, involved in drug compounding and drug production, to 5-fluorouracil (5FU) was studied. 5FU was found by the analysis of air and wipe samples. During weighing, 5FU was detected in the air (75 µg/m³). 5FU was also present on the filter of the mask of the weigher (120 µg). Before drug compounding 5FU was found on the floor (range,
ISSN:	0096-1736 2332-3795