Donor-recipient race-ethnicity concordance and patient survival after liver transplantation
We assessed the association between patient survival after liver transplantation (LT) and donor-recipient race-ethnicity (R/E) concordance. The Scientific Registry of Transplant Recipients (SRTR) was retrospectively analyzed using data collected between 2002 and 2019. Only adults without history of...
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| Veröffentlicht in: | HPB (Oxford, England) England), 2024-06, Vol.26 (6), p.772-781 |
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| creator | Laffey, Makenna Ashwat, Eishan Lui, Hao Zhang, Xingyu Kaltenmeier, Christof Packiaraj, Godwin Crane, Andrew Alshamery, Sarmad Gunabushanam, Vikraman Ganoza, Armando Dharmayan, Stalin Powers, Colin A. Jonassaint, Naudia Molinari, Michele |
| description | We assessed the association between patient survival after liver transplantation (LT) and donor-recipient race-ethnicity (R/E) concordance.
The Scientific Registry of Transplant Recipients (SRTR) was retrospectively analyzed using data collected between 2002 and 2019. Only adults without history of prior organ transplant and recipients of LT alone were included. The primary outcome was patient survival. Donors and recipients were categorized into five R/E groups: White/Caucasian, African American/Black, Hispanic/Latino, Asian, and Others. Statistical analyses were performed using Kaplan–Meier survival curves and Cox Proportional Hazards models, adjusting for donor and recipient covariates.
85,427 patients were included. Among all the R/E groups, Asian patients had the highest 5-year survival (81.3%; 95% CI = 79.9–82.7), while African American/Black patients had the lowest (71.4%; 95% CI = 70.3–72.6) (P |
| doi_str_mv | 10.1016/j.hpb.2024.03.003 |
| format | Article |
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The Scientific Registry of Transplant Recipients (SRTR) was retrospectively analyzed using data collected between 2002 and 2019. Only adults without history of prior organ transplant and recipients of LT alone were included. The primary outcome was patient survival. Donors and recipients were categorized into five R/E groups: White/Caucasian, African American/Black, Hispanic/Latino, Asian, and Others. Statistical analyses were performed using Kaplan–Meier survival curves and Cox Proportional Hazards models, adjusting for donor and recipient covariates.
85,427 patients were included. Among all the R/E groups, Asian patients had the highest 5-year survival (81.3%; 95% CI = 79.9–82.7), while African American/Black patients had the lowest (71.4%; 95% CI = 70.3–72.6) (P < 0.001). Lower survival rates were observed in recipients who received discordant R/E grafts irrespective of their R/E group. The fully adjusted hazard ratio for death was statistically significant in African American/Black (aHR 1.07–1.18-1.31; P < 0.01) and in White∕Caucasian patients (aHR 1.00-1.04-1.07; P = 0.03) in the presence of donor-recipient R/E discordance.
Disparities in post-LT outcomes might be influenced by biological factors in addition to well-known social determinants of health.
[Display omitted]</description><identifier>ISSN: 1365-182X</identifier><identifier>ISSN: 1477-2574</identifier><identifier>EISSN: 1477-2574</identifier><identifier>DOI: 10.1016/j.hpb.2024.03.003</identifier><identifier>PMID: 38523016</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; Asian ; Black or African American ; Ethnicity - statistics & numerical data ; Female ; Hispanic or Latino ; Humans ; Liver Transplantation - mortality ; Male ; Middle Aged ; Racial Groups ; Registries ; Retrospective Studies ; Risk Factors ; Survival Rate ; Tissue Donors ; United States - epidemiology ; White</subject><ispartof>HPB (Oxford, England), 2024-06, Vol.26 (6), p.772-781</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c305t-c9b1af8995e94553dfdf0e9b5171acd029b6548ced17fa05b7fd7aa6732ed0163</cites><orcidid>0000-0002-9763-6253 ; 0000-0002-2413-4463</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38523016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laffey, Makenna</creatorcontrib><creatorcontrib>Ashwat, Eishan</creatorcontrib><creatorcontrib>Lui, Hao</creatorcontrib><creatorcontrib>Zhang, Xingyu</creatorcontrib><creatorcontrib>Kaltenmeier, Christof</creatorcontrib><creatorcontrib>Packiaraj, Godwin</creatorcontrib><creatorcontrib>Crane, Andrew</creatorcontrib><creatorcontrib>Alshamery, Sarmad</creatorcontrib><creatorcontrib>Gunabushanam, Vikraman</creatorcontrib><creatorcontrib>Ganoza, Armando</creatorcontrib><creatorcontrib>Dharmayan, Stalin</creatorcontrib><creatorcontrib>Powers, Colin A.</creatorcontrib><creatorcontrib>Jonassaint, Naudia</creatorcontrib><creatorcontrib>Molinari, Michele</creatorcontrib><title>Donor-recipient race-ethnicity concordance and patient survival after liver transplantation</title><title>HPB (Oxford, England)</title><addtitle>HPB (Oxford)</addtitle><description>We assessed the association between patient survival after liver transplantation (LT) and donor-recipient race-ethnicity (R/E) concordance.
The Scientific Registry of Transplant Recipients (SRTR) was retrospectively analyzed using data collected between 2002 and 2019. Only adults without history of prior organ transplant and recipients of LT alone were included. The primary outcome was patient survival. Donors and recipients were categorized into five R/E groups: White/Caucasian, African American/Black, Hispanic/Latino, Asian, and Others. Statistical analyses were performed using Kaplan–Meier survival curves and Cox Proportional Hazards models, adjusting for donor and recipient covariates.
85,427 patients were included. Among all the R/E groups, Asian patients had the highest 5-year survival (81.3%; 95% CI = 79.9–82.7), while African American/Black patients had the lowest (71.4%; 95% CI = 70.3–72.6) (P < 0.001). Lower survival rates were observed in recipients who received discordant R/E grafts irrespective of their R/E group. The fully adjusted hazard ratio for death was statistically significant in African American/Black (aHR 1.07–1.18-1.31; P < 0.01) and in White∕Caucasian patients (aHR 1.00-1.04-1.07; P = 0.03) in the presence of donor-recipient R/E discordance.
Disparities in post-LT outcomes might be influenced by biological factors in addition to well-known social determinants of health.
[Display omitted]</description><subject>Adult</subject><subject>Aged</subject><subject>Asian</subject><subject>Black or African American</subject><subject>Ethnicity - statistics & numerical data</subject><subject>Female</subject><subject>Hispanic or Latino</subject><subject>Humans</subject><subject>Liver Transplantation - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Racial Groups</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><subject>Tissue Donors</subject><subject>United States - epidemiology</subject><subject>White</subject><issn>1365-182X</issn><issn>1477-2574</issn><issn>1477-2574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtKBDEUhoMo3h_ARqa0mTGXyWaClXgHwUZBsAiZ5AxmmU3GJLvg2xvd1dImJ8X3_5zzIXRCcEMwmZ3Pm_epbyimbYNZgzHbQvukFaKmXLTb5c9mvCYdfd1DBynNMaYlJnfRHus4ZaVhH71dBx9iHcG4yYHPVdQGasjv3hmXPysTvAnRam-g0t5Wk84_WFrGlVvpsdJDhliNblXeHLVP06h9LlTwR2hn0GOC4808RC-3N89X9_Xj093D1eVjbRjmuTayJ3ropOQgW86ZHeyAQfacCKKNxVT2M952BiwRg8a8F4MVWs8Eo2DLEewQna17pxg-lpCyWrhkYCyLQFgmRWXHhRRC4oKSNWpiSCnCoKboFjp-KoLVt1M1V8Wp-naqMFPFacmcbuqX_QLsX-JXYgEu1gCUI1cOokqmSCoLu-I1KxvcP_VfpG2JYQ</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Laffey, Makenna</creator><creator>Ashwat, Eishan</creator><creator>Lui, Hao</creator><creator>Zhang, Xingyu</creator><creator>Kaltenmeier, Christof</creator><creator>Packiaraj, Godwin</creator><creator>Crane, Andrew</creator><creator>Alshamery, Sarmad</creator><creator>Gunabushanam, Vikraman</creator><creator>Ganoza, Armando</creator><creator>Dharmayan, Stalin</creator><creator>Powers, Colin A.</creator><creator>Jonassaint, Naudia</creator><creator>Molinari, Michele</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9763-6253</orcidid><orcidid>https://orcid.org/0000-0002-2413-4463</orcidid></search><sort><creationdate>202406</creationdate><title>Donor-recipient race-ethnicity concordance and patient survival after liver transplantation</title><author>Laffey, Makenna ; 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The Scientific Registry of Transplant Recipients (SRTR) was retrospectively analyzed using data collected between 2002 and 2019. Only adults without history of prior organ transplant and recipients of LT alone were included. The primary outcome was patient survival. Donors and recipients were categorized into five R/E groups: White/Caucasian, African American/Black, Hispanic/Latino, Asian, and Others. Statistical analyses were performed using Kaplan–Meier survival curves and Cox Proportional Hazards models, adjusting for donor and recipient covariates.
85,427 patients were included. Among all the R/E groups, Asian patients had the highest 5-year survival (81.3%; 95% CI = 79.9–82.7), while African American/Black patients had the lowest (71.4%; 95% CI = 70.3–72.6) (P < 0.001). Lower survival rates were observed in recipients who received discordant R/E grafts irrespective of their R/E group. The fully adjusted hazard ratio for death was statistically significant in African American/Black (aHR 1.07–1.18-1.31; P < 0.01) and in White∕Caucasian patients (aHR 1.00-1.04-1.07; P = 0.03) in the presence of donor-recipient R/E discordance.
Disparities in post-LT outcomes might be influenced by biological factors in addition to well-known social determinants of health.
[Display omitted]</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38523016</pmid><doi>10.1016/j.hpb.2024.03.003</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9763-6253</orcidid><orcidid>https://orcid.org/0000-0002-2413-4463</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Asian Black or African American Ethnicity - statistics & numerical data Female Hispanic or Latino Humans Liver Transplantation - mortality Male Middle Aged Racial Groups Registries Retrospective Studies Risk Factors Survival Rate Tissue Donors United States - epidemiology White |
| title | Donor-recipient race-ethnicity concordance and patient survival after liver transplantation |
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