Genotoxic Potential of Regenerated Silk Fibroin Films by Different Cross-Linking Mode
Emerging studies have showed that silk fibroin might be as a naturally occurring degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi s study, we examined the geno...
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Veröffentlicht in: | Key engineering materials 2007-07, Vol.342-343, p.257-260 |
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container_title | Key engineering materials |
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creator | Miao, Jing Cheng Sheng, Wei Hua Li, Ming Zhong Xie, Yu Feng Yang, Ji Cheng Gong, Ai Hua |
description | Emerging studies have showed that silk fibroin might be as a naturally occurring
degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib
ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi
s study, we examined the genotoxic potential of the regenerated silk fibroin films by differe
nt cross-linking mode with micronucleus and the single cell gel electrophoresis (comet) assa
y. The data showed that MNF in group PC and group SD showed significantly no differenc
e with blank group (P>0.05), and no evident comet tails were observed. However, the resul
t of EC group was significantly different from the control group(P |
doi_str_mv | 10.4028/www.scientific.net/KEM.342-343.257 |
format | Article |
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degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib
ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi
s study, we examined the genotoxic potential of the regenerated silk fibroin films by differe
nt cross-linking mode with micronucleus and the single cell gel electrophoresis (comet) assa
y. The data showed that MNF in group PC and group SD showed significantly no differenc
e with blank group (P>0.05), and no evident comet tails were observed. However, the resul
t of EC group was significantly different from the control group(P<0.01). Taken together, R
SFFs in group PC and group SD have no evident genotoxicity, which is better than group
EC.</description><identifier>ISSN: 1013-9826</identifier><identifier>ISSN: 1662-9795</identifier><identifier>EISSN: 1662-9795</identifier><identifier>DOI: 10.4028/www.scientific.net/KEM.342-343.257</identifier><language>eng</language><publisher>Trans Tech Publications Ltd</publisher><ispartof>Key engineering materials, 2007-07, Vol.342-343, p.257-260</ispartof><rights>2007 Trans Tech Publications Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-b2135e3e61f90a3956136eb0c2ae5bff16b38066a794cb1a791e06473aa07743</citedby><cites>FETCH-LOGICAL-c301t-b2135e3e61f90a3956136eb0c2ae5bff16b38066a794cb1a791e06473aa07743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://www.scientific.net/Image/TitleCover/66?width=600</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Miao, Jing Cheng</creatorcontrib><creatorcontrib>Sheng, Wei Hua</creatorcontrib><creatorcontrib>Li, Ming Zhong</creatorcontrib><creatorcontrib>Xie, Yu Feng</creatorcontrib><creatorcontrib>Yang, Ji Cheng</creatorcontrib><creatorcontrib>Gong, Ai Hua</creatorcontrib><title>Genotoxic Potential of Regenerated Silk Fibroin Films by Different Cross-Linking Mode</title><title>Key engineering materials</title><description>Emerging studies have showed that silk fibroin might be as a naturally occurring
degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib
ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi
s study, we examined the genotoxic potential of the regenerated silk fibroin films by differe
nt cross-linking mode with micronucleus and the single cell gel electrophoresis (comet) assa
y. The data showed that MNF in group PC and group SD showed significantly no differenc
e with blank group (P>0.05), and no evident comet tails were observed. However, the resul
t of EC group was significantly different from the control group(P<0.01). Taken together, R
SFFs in group PC and group SD have no evident genotoxicity, which is better than group
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degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib
ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi
s study, we examined the genotoxic potential of the regenerated silk fibroin films by differe
nt cross-linking mode with micronucleus and the single cell gel electrophoresis (comet) assa
y. The data showed that MNF in group PC and group SD showed significantly no differenc
e with blank group (P>0.05), and no evident comet tails were observed. However, the resul
t of EC group was significantly different from the control group(P<0.01). Taken together, R
SFFs in group PC and group SD have no evident genotoxicity, which is better than group
EC.</abstract><pub>Trans Tech Publications Ltd</pub><doi>10.4028/www.scientific.net/KEM.342-343.257</doi><tpages>4</tpages></addata></record> |
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title | Genotoxic Potential of Regenerated Silk Fibroin Films by Different Cross-Linking Mode |
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