Genotoxic Potential of Regenerated Silk Fibroin Films by Different Cross-Linking Mode

Emerging studies have showed that silk fibroin might be as a naturally occurring degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi s study, we examined the geno...

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Veröffentlicht in:Key engineering materials 2007-07, Vol.342-343, p.257-260
Hauptverfasser: Miao, Jing Cheng, Sheng, Wei Hua, Li, Ming Zhong, Xie, Yu Feng, Yang, Ji Cheng, Gong, Ai Hua
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Sheng, Wei Hua
Li, Ming Zhong
Xie, Yu Feng
Yang, Ji Cheng
Gong, Ai Hua
description Emerging studies have showed that silk fibroin might be as a naturally occurring degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi s study, we examined the genotoxic potential of the regenerated silk fibroin films by differe nt cross-linking mode with micronucleus and the single cell gel electrophoresis (comet) assa y. The data showed that MNF in group PC and group SD showed significantly no differenc e with blank group (P>0.05), and no evident comet tails were observed. However, the resul t of EC group was significantly different from the control group(P
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