Genotoxic Potential of Regenerated Silk Fibroin Films by Different Cross-Linking Mode
Emerging studies have showed that silk fibroin might be as a naturally occurring degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi s study, we examined the geno...
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Veröffentlicht in: | Key engineering materials 2007-07, Vol.342-343, p.257-260 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Emerging studies have showed that silk fibroin might be as a naturally occurring
degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib
ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi
s study, we examined the genotoxic potential of the regenerated silk fibroin films by differe
nt cross-linking mode with micronucleus and the single cell gel electrophoresis (comet) assa
y. The data showed that MNF in group PC and group SD showed significantly no differenc
e with blank group (P>0.05), and no evident comet tails were observed. However, the resul
t of EC group was significantly different from the control group(P |
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ISSN: | 1013-9826 1662-9795 1662-9795 |
DOI: | 10.4028/www.scientific.net/KEM.342-343.257 |