XAS Characterization of the Zn Site of Non-structural Protein 3 (NS3) from Hepatitis C Virus

XAS Characterization of the Zn Site of Non-structural Protein 3 (NS3) from Hepatitis C Virus

XANES spectra of non structural protein 3 (NS3) have been calculated using 4 Zn coordination models from three crystallographic structures in the Protein Data Base (PDB): 1DY9, subunit B, 1CU1 subunit A and B, and 1JXP subunit B. Results indicate that XANES is an appropriate tool to distinguish amon...

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Bibliographische Detailangaben
Hauptverfasser: Ascone, I, Nobili, G, Benfatto, M, Congiu-Castellano, A
Format: Tagungsbericht
Sprache:eng
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Zusammenfassung:XANES spectra of non structural protein 3 (NS3) have been calculated using 4 Zn coordination models from three crystallographic structures in the Protein Data Base (PDB): 1DY9, subunit B, 1CU1 subunit A and B, and 1JXP subunit B. Results indicate that XANES is an appropriate tool to distinguish among them. Experimental XANES spectra have been simulated refining crystallographic data. The model obtained by XAS is compared with the PDB models.
ISSN:0094-243X
DOI:10.1063/1.2644511