Okichromanone, a new antiviral chromanone from a marine-derived Microbispora
Okichromanone ( 1 ), a new chromanone, was isolated from the culture extract of a sponge-derived actinomycete Microbispora , along with known 1-hydroxyphenazine ( 2 ). Compound 1 was elucidated to exist as a mixture of two isomeric structures ( 1a and 1b ) at a ratio of nearly 3:2. Compounds 1 and 2...
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| Veröffentlicht in: | Journal of antibiotics 2024-06, Vol.77 (6), p.389-392 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Okichromanone (
1
), a new chromanone, was isolated from the culture extract of a sponge-derived actinomycete
Microbispora
, along with known 1-hydroxyphenazine (
2
). Compound
1
was elucidated to exist as a mixture of two isomeric structures (
1a
and
1b
) at a ratio of nearly 3:2. Compounds
1
and
2
showed anti HSV-I activity with IC
50
values 40 and 86 μM, respectively, and anti HSV-II activity with IC
50
values 59 and 123 μM, respectively. |
|---|---|
| ISSN: | 0021-8820 1881-1469 1881-1469 |
| DOI: | 10.1038/s41429-024-00718-2 |