Interaction effects of MTHFR C677T and A1298C polymorphisms with maternal glycated haemoglobin levels on adverse birth outcomes

Interaction effects of MTHFR C677T and A1298C polymorphisms with maternal glycated haemoglobin levels on adverse birth outcomes

Aims The role of maternal genetic factors in the association between high glycated haemoglobin (HbA1c) levels and adverse birth outcomes remains unclear. Materials and Methods In this study, the maternal HbA1c levels of 5108 normoglycemic pregnant women in China were measured, and A1298C and C677T p...

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Veröffentlicht in:Diabetes/metabolism research and reviews 2024-03, Vol.40 (3), p.e3794-n/a
Hauptverfasser: Wu, Weixiang, Luo, Dan, Ji, Cunwei, Diao, Fuqiang, Wu, Lihong, Ruan, Xiaolin, Gu, Chunming, Luo, Mingyong
Format: Artikel
Sprache:eng
Schlagworte:
adverse birth outcomes
Age
Birth
Genetic factors
Genotype & phenotype
Gestational age
glycated haemoglobin
Hemoglobin
interaction effect
Methylenetetrahydrofolate reductase
methylenetetrahydrofolate reductase polymorphisms
Pregnancy
Premature birth
preterm birth
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Zusammenfassung:Aims The role of maternal genetic factors in the association between high glycated haemoglobin (HbA1c) levels and adverse birth outcomes remains unclear. Materials and Methods In this study, the maternal HbA1c levels of 5108 normoglycemic pregnant women in China were measured, and A1298C and C677T polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene were genotyped. Results Elevated HbA1c levels during the second trimester were associated with increased risks of macrosomia, large‐for‐gestational age (LGA), preterm birth (PTB), and reduced gestational age (p 
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.3794