Health literacy, governance and systems leadership contribute to the implementation of the One Health approach: a virtuous circle

•Governance and health literacy are essential to meet the one health challenge.•We propose a self-reinforcing process to contribute to the one health approach.•Four challenges may inhibit the implementation of the one health approach.•Systems leadership is a catalyst to increasing one health governance and literacy.•Systems leadership must span across society, policy, health, academia and industry. One Health is an important approach to addressing health threats and promoting health through interdisciplinary health, policy, legislation and leadership research to achieve better human and animal health and better outcomes for the planet. The Covid-19 pandemic has triggered an urgent awareness of the need to develop innovative integrative solutions to address root causes of such threats to health, which requires collaboration across disciplines and amongst different sectors and communities. We explore how achieving the Quadripartite Organizations’ One Health Joint Plan of Action can be supported by the concepts of ‘One Health literacy’ and ‘One Health governance’ and promote both academic and policy dialogue. We show how One Health literacy and One Health governance influence and reinforce each other, while an interdisciplinary systems leadership approach acts as a catalyst and mechanism for understanding and enacting change. Based on our understanding of how these elements influence the implementation of the One Health approach, we describe a model for considering how external triggering events such as the Covid-19 pandemic may prompt a virtuous circle whereby exposure to and exploration of One Health issues may lead to improved One Health literacy and to better governance. We close with recommendations to international organisations, national governments and to leaders in policy, research and practice to enhance their influence on society, the planetary environment, health and well-being.