A SIFI odyssey: Silencing the stress response amid mitochondrial import blockade to safeguard cell survival

A SIFI odyssey: Silencing the stress response amid mitochondrial import blockade to safeguard cell survival

In a recent study in Nature, Haakonsen et al.1 identify the SIFI complex as a stress response silencer via its E3 ligase activity to target unimported mitochondrial proteins and stress response components for degradation via the proteasome. In a recent study in Nature, Haakonsen et al. identify the...

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Veröffentlicht in:Molecular cell 2024-03, Vol.84 (6), p.1000-1002
Hauptverfasser: Martinez Castillo, Yuleika G., Evans, Chantell S.
Format: Artikel
Sprache:eng
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Zusammenfassung:In a recent study in Nature, Haakonsen et al.1 identify the SIFI complex as a stress response silencer via its E3 ligase activity to target unimported mitochondrial proteins and stress response components for degradation via the proteasome. In a recent study in Nature, Haakonsen et al. identify the SIFI complex as a stress response silencer via its E3 ligase activity to target unimported mitochondrial proteins and stress response components for degradation via the proteasome.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2024.02.034