FIRRM and FIGNL1: partners in the regulation of homologous recombination

DNA repair through homologous recombination (HR) is of vital importance for maintaining genome stability and preventing tumorigenesis. RAD51 is the core component of HR, catalyzing the strand invasion and homology search. Here, we highlight recent findings on FIRRM and FIGNL1 as regulators of the dy...

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Veröffentlicht in:	Trends in genetics 2024-06, Vol.40 (6), p.467-470
Hauptverfasser:	Tsaridou, Stavroula, van Vugt, Marcel A.T.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals C1orf112 DNA Repair - genetics FIGNL1 FIRRM Genomic Instability - genetics homologous recombination Homologous Recombination - genetics Humans RAD51 Rad51 Recombinase - genetics Rad51 Recombinase - metabolism
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Beschreibung
Zusammenfassung:	DNA repair through homologous recombination (HR) is of vital importance for maintaining genome stability and preventing tumorigenesis. RAD51 is the core component of HR, catalyzing the strand invasion and homology search. Here, we highlight recent findings on FIRRM and FIGNL1 as regulators of the dynamics of RAD51. DNA repair through homologous recombination (HR) is of vital importance for maintaining genome stability and preventing tumorigenesis. RAD51 is the core component of HR, catalyzing the strand invasion and homology search. Here, we highlight recent findings on FIRRM and FIGNL1 as regulators of the dynamics of RAD51.
ISSN:	0168-9525
DOI:	10.1016/j.tig.2024.02.007