Disrupted TGF-β signaling: a link between bronchopulmonary dysplasia and alveolar type 1 cells

Bronchopulmonary dysplasia (BPD) is a chronic lung disease common in extreme preterm infants and is characterized by alveolar simplification. Current BPD research mainly focuses on alveolar type 2 (AT2) cells, myofibroblasts, and the endothelium. However, a notable gap exists in the involvement of A...

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Veröffentlicht in:The Journal of clinical investigation 2024-03, Vol.134 (6)
1. Verfasser: Li, Rongbo
Format: Artikel
Sprache:eng
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Zusammenfassung:Bronchopulmonary dysplasia (BPD) is a chronic lung disease common in extreme preterm infants and is characterized by alveolar simplification. Current BPD research mainly focuses on alveolar type 2 (AT2) cells, myofibroblasts, and the endothelium. However, a notable gap exists in the involvement of AT1 cells, which constitute a majority of the alveolar surface area. In this issue of the JCI, Callaway and colleagues explored the role of TGF-β signaling in AT1 cells for managing the AT1-to-AT2 transition and its involvement in the integration of mechanical forces with the pulmonary matrisome during development. The findings implicate AT1 cells in the pathogenesis of BPD.
ISSN:1558-8238
1558-8238
DOI:10.1172/JCI178562