Clinical Impact of Vancomycin MIC on Outcomes in Patients With Coagulase-negative Staphylococcal Bacteremia

Coagulase-negative staphylococci (CoNS) are Gram-positive organisms that are a known component of normal skin flora and the most common cause of nosocomial bacteremia. For CoNS species, the vancomycin MIC breakpoint for susceptibility set by the Clinical and Laboratory Standards Institute is ≤4 µg/m...

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Veröffentlicht in:	Clinical therapeutics 2024-06, Vol.46 (6), p.444-450
Hauptverfasser:	Wheat, Wade, Simiyu, Brenda, Andonie, Gabriela, Bellfi, Lillian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Bacteremia Blood culture Bloodstream infection Catheters Coagulase Coagulase-negative staphylococci Electronic health records Endocarditis Health care facilities Hospitals Impact analysis Laboratories Medical records MIC Minimum inhibitory concentration Mortality Nosocomial infection Nosocomial infections Outcomes Oxacillin Patients Staphylococcus epidermidis Staphylococcus infections Vancomycin Virulence
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Zusammenfassung:	Coagulase-negative staphylococci (CoNS) are Gram-positive organisms that are a known component of normal skin flora and the most common cause of nosocomial bacteremia. For CoNS species, the vancomycin MIC breakpoint for susceptibility set by the Clinical and Laboratory Standards Institute is ≤4 µg/mL. There has been published reports of vancomycin heteroresistance in CoNS with vancomycin MICs of 2 to 4 µg/mL. The aim of this retrospective cohort analysis was to assess the clinical impact of vancomycin MICs
ISSN:	0149-2918 1879-114X 1879-114X
DOI:	10.1016/j.clinthera.2024.01.012