SiNiSan exerts antidepressant effects by modulating serotonergic/GABAergic neuron activity in the dorsal raphe nucleus region through NMDA receptor in the adolescent depression mouse model

SiNiSan exerts antidepressant effects by modulating serotonergic/GABAergic neuron activity in the dorsal raphe nucleus region through NMDA receptor in the adolescent depression mouse model

[Display omitted] •SiNiSan exerts therapeutic effects on adolescent depression caused by stress in early life and adolescence.•SiNiSan downregulates N-methyl-D-aspartic acid (NMDA) receptor expression and regulates serotonergic/GABAergic neuron activity in theDRN region of adolescent depression mode...

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Veröffentlicht in:Journal of ethnopharmacology 2024-06, Vol.328, p.118040-118040, Article 118040
Hauptverfasser: Cao, Kerun, Zhong, Jialong, Wang, Shanshan, Shi, Yafei, Bai, Shasha, Zhao, Jinlan, Yang, Lei, Liang, Qi, Deng, Di, Zhang, Rong
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container_title Journal of ethnopharmacology
container_volume 328
creator Cao, Kerun
Zhong, Jialong
Wang, Shanshan
Shi, Yafei
Bai, Shasha
Zhao, Jinlan
Yang, Lei
Liang, Qi
Deng, Di
Zhang, Rong
description [Display omitted] •SiNiSan exerts therapeutic effects on adolescent depression caused by stress in early life and adolescence.•SiNiSan downregulates N-methyl-D-aspartic acid (NMDA) receptor expression and regulates serotonergic/GABAergic neuron activity in theDRN region of adolescent depression models.•SiNiSan regulates neuronal activity by downregulating NMDA receptors in DRN of adolescent depression models.
doi_str_mv 10.1016/j.jep.2024.118040
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title SiNiSan exerts antidepressant effects by modulating serotonergic/GABAergic neuron activity in the dorsal raphe nucleus region through NMDA receptor in the adolescent depression mouse model
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