SiNiSan exerts antidepressant effects by modulating serotonergic/GABAergic neuron activity in the dorsal raphe nucleus region through NMDA receptor in the adolescent depression mouse model

[Display omitted] •SiNiSan exerts therapeutic effects on adolescent depression caused by stress in early life and adolescence.•SiNiSan downregulates N-methyl-D-aspartic acid (NMDA) receptor expression and regulates serotonergic/GABAergic neuron activity in theDRN region of adolescent depression models.•SiNiSan regulates neuronal activity by downregulating NMDA receptors in DRN of adolescent depression models.