Space‐Efficient 3D Microalgae Farming with Optimized Resource Utilization for Regenerative Food

Photosynthetic microalgae produce valuable metabolites and are a source of sustainable food that supports life without compromising arable land. However, the light self‐shading, excessive water supply, and insufficient space utilization in microalgae farming have limited its potential in the inland areas most in need of regenerative food solutions. Herein, this work develops a 3D polysaccharide‐based hydrogel scaffold for vertically farming microalgae without needing liquid media. This liquid‐free strategy is compatible with diverse microalgal species and enables the design of living microalgal frameworks with customizable architectures that enhance light and water utilization. This approach significantly increases microalgae yield per unit water consumption, with an 8.8‐fold increase compared to traditional methods. Furthermore, the dehydrated hydrogels demonstrate a reduced size and weight (≈70% reduction), but readily recover their vitality upon rehydration. Importantly, valuable natural products can be produced in this system including proteins, carbohydrates, lipids, and carotenoids. This study streamlines microalgae regenerative farming for low‐carbon biomanufacturing by minimizing light self‐shading, relieving water supply, and reducing physical footprints, and democratizing access to efficient aquatic food production. The integration of 3D bioprinting and vertical agriculture offers promising opportunities for cultivating microalgae as regenerative food resource. Biogenic systems that incorporate microalgae in rational design of hydrogels significantly boost microalgae yield for each unit of water consumed. This strategy addresses critical challenges including self‐shading effects and inefficient space utilization, paving the way for more accessible and sustainable food production.