RSV Prefusion F Protein–Based Maternal Vaccine — Preterm Birth and Other Outcomes

An RSV prefusion F maternal vaccine was assessed for efficacy against RSV disease in infants. The trial was stopped early owing to a higher incidence of preterm birth in the vaccine group than in the placebo group.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2024-03, Vol.390 (11), p.1009-1021
Hauptverfasser:	Dieussaert, Ilse, Hyung Kim, Joon, Luik, Sabine, Seidl, Claudia, Pu, Wenji, Stegmann, Jens-Ulrich, Swamy, Geeta K., Webster, Peggy, Dormitzer, Philip R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Birth Childhood Diseases Complications of Pregnancy F protein Female Gynecology Gynecology General Humans Immunization Infant Infant, Newborn Infants Infectious Disease Investigations Neonates Obstetrics Pediatrics Pediatrics General Placebos Pregnancy Premature Birth Respiratory syncytial virus Respiratory Syncytial Virus Infections Respiratory Syncytial Virus Vaccines Respiratory Syncytial Virus, Human Respiratory Tract Diseases Safety Vaccine efficacy Vaccines Viral Infections Womens health
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Beschreibung
Zusammenfassung:	An RSV prefusion F maternal vaccine was assessed for efficacy against RSV disease in infants. The trial was stopped early owing to a higher incidence of preterm birth in the vaccine group than in the placebo group.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2305478