Aging-accumulated methylmalonic acid serum levels at breast cancer diagnosis are not associated with distant metastases
Purpose Recent evidence suggests that age-accumulated methylmalonic acid (MMA) promotes breast cancer progression in mice. This study aims to investigate the association between baseline serum MMA concentrations in patients with breast cancer and the development of subsequent distant metastases. Met...
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Veröffentlicht in: | Breast cancer research and treatment 2024-06, Vol.205 (3), p.555-565 |
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Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Purpose
Recent evidence suggests that age-accumulated methylmalonic acid (MMA) promotes breast cancer progression in mice. This study aims to investigate the association between baseline serum MMA concentrations in patients with breast cancer and the development of subsequent distant metastases.
Methods
We included 32 patients with early Luminal B-like breast cancer (LumB, median age 62.4y) and 52 patients with early triple-negative breast cancer (TNBC, median age 50.5y) who developed distant metastases within 5 years. They were matched to an equal number of early breast cancer patients (median age 62.2y for LumB and 50.5y for TNBC) who did not develop distant metastases with at least 5 years of follow-up.
Results
Baseline serum MMA levels at breast cancer diagnosis showed a positive correlation with age (
P
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ISSN: | 0167-6806 1573-7217 1573-7217 |
DOI: | 10.1007/s10549-024-07260-7 |