Evaluation of human papillomavirus type 16 viral load and genome physical status in Iranian women with cervical disease

Evaluation of human papillomavirus type 16 viral load and genome physical status in Iranian women with cervical disease

Background This study examined the viral load and physical status of the human papillomavirus 16 (HPV-16) genome in non-cancerous, precancerous and cancerous cervical lesions. Methods Quantitative real-time PCR was performed to determine HPV-16 E2 and E6 viral load in 132 cervical specimens. E2/E6 v...

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Veröffentlicht in:Molecular biology reports 2024-12, Vol.51 (1), p.411-411, Article 411
Hauptverfasser: Setayeshi, Shadi, Hasanzadeh, Ali, Yahyapour, Yousef, Alizadeh, Ahad, Ghorbani, Hossein, Nokhostin, Fahimeh, Bagheri, Meghdad, Sadeghi, Farzin
Format: Artikel
Sprache:eng
Schlagworte:
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Cell cycle
Cervical cancer
Cloning
DNA polymerase
E2 gene
E6 gene
Genomes
Histology
Hospitals
Human papillomavirus
Infections
Life Sciences
Medical research
Medical screening
Medicine
Molecular biology
Morphology
Original Article
Pap smear
Proteins
Research centers
Viral infections
Viruses
Womens health
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Zusammenfassung:Background This study examined the viral load and physical status of the human papillomavirus 16 (HPV-16) genome in non-cancerous, precancerous and cancerous cervical lesions. Methods Quantitative real-time PCR was performed to determine HPV-16 E2 and E6 viral load in 132 cervical specimens. E2/E6 viral load ratio was used to determine the physical status of HPV-16 genome. Results E2 gene viral load was a significant (P 
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-024-09397-6