Presence of carbazole and polyhalogenated carbazoles in human urine

Exposure to carbazole (CZ) and polyhalogenated carbazoles (PHCZs) may pose a threat to human health, owing to their potential dioxin-like toxicity. Until now, the presence of these chemicals in the human urine from the general population is still unclear. Human urine samples (n = 210) were taken fro...

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Veröffentlicht in:The Science of the total environment 2024-05, Vol.923, p.171609-171609, Article 171609
Hauptverfasser: Mao, Weili, Jin, Hangbiao, Yin, Sihui, Xu, Luyao, Guo, Ruyue, Mao, Kaili
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Sprache:eng
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Zusammenfassung:Exposure to carbazole (CZ) and polyhalogenated carbazoles (PHCZs) may pose a threat to human health, owing to their potential dioxin-like toxicity. Until now, the presence of these chemicals in the human urine from the general population is still unclear. Human urine samples (n = 210) were taken from the general population in Quzhou, China in this study, and were analyzed for CZ and 14 PHCZs. CZ and nine PHCZs were detected in collected human urine. CZ (detection frequency 100 %), 3-chlorocarbazole (3-CCZ; 88 %), 3,6-dichlorocarbzole (36-CCZ; 84 %), and 3-bromocarbazole (3-BCZ; 80 %) were more frequently detected. Among detected PHCZs, 3-CCZ (mean 0.49 ng/mL, < LOD–4.3 ng/mL) had comparatively higher urinary levels, followed by 3-BCZ (0.30 ng/L, < LOD–1.9 ng/mL) and 36-CCZ (0.20 ng/L, < LOD–1.4 ng/mL). Urinary concentrations of CZ in male participants (1.3 ± 0.26 ng/mL) were significantly (p 
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2024.171609