Clinical features and prognostic factors of nasopharyngeal carcinoma with brain metastases

•Novelty and Impact: As one of the most extensive analyses of NPC brain metastases to date, our research emphasizes the substantial prognostic improvement through local therapeutic post-brain metastasis, particularly with the application of radiation therapy. Brain metastasis in nasopharyngeal carci...

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Veröffentlicht in:Oral oncology 2024-04, Vol.151, p.106738-106738, Article 106738
Hauptverfasser: Chen, Kehui, Shi, Mengting, Mo, Silang, Liu, Tingting, Zhao, Yuanyuan, Zhang, Li, Zhao, Shen
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Sprache:eng
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Zusammenfassung:•Novelty and Impact: As one of the most extensive analyses of NPC brain metastases to date, our research emphasizes the substantial prognostic improvement through local therapeutic post-brain metastasis, particularly with the application of radiation therapy. Brain metastasis in nasopharyngeal carcinoma is a rare occurrence, and the characteristics of patients in this subgroup remain poorly defined. This study aims to delineate the clinical features, treatment modalities, prognostic factors, and survival of nasopharyngeal carcinoma patients with brain metastasis. A retrospective analysis was conducted on patients diagnosed with nasopharyngeal carcinoma who developed brain metastasis and were treated at the Sun Yat-sen University Cancer Center between July 2000 and July 2023. Clinical data from patients were collected and used to assess their survival after brain metastases and prognostic factors. Among 82,434 nasopharyngeal carcinoma patients, 40 (0.06 %) developed Brain metastasis with a median follow-up of 5.1 years. The predominant histological subtype was non-keratinizing squamous cell carcinoma (85 %). The median post-BM survival was 25 months. The age, the Eastern Cooperative Oncology Group (ECOG), and the procedural treatment of BM were prognostic factors. Notably, patients receiving local treatments had significantly prolonged post-BM survival compared to those receiving systemic therapy alone (median, 47.00 vs. 11.00 months; p = 0.011). This is the largest cohort of brain metastasis in nasopharyngeal carcinoma to date. Local therapeutic measures after brain metastasis can significantly enhance the prognosis of these patients, particularly when radiotherapy is applied.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2024.106738