Immunogenic Xist ribonucleoproteins drive sex-biased autoimmunity

Immunogenic Xist ribonucleoproteins drive sex-biased autoimmunity

Ribonucleoprotein complexes containing Xist, a long non-coding RNA involved in X chromosome inactivation, are immunogenic and promote autoimmune responses.

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Bibliographische Detailangaben
Veröffentlicht in:Nature reviews. Rheumatology 2024-04, Vol.20 (4), p.198-198
1. Verfasser: McHugh, Jessica
Format: Artikel
Sprache:eng
Schlagworte:
631/250/249/1313
631/250/249/1313/1613
Autoimmunity
Humans
Immunogenicity
Medicine
Medicine & Public Health
Research Highlight
Rheumatology
Ribonucleoproteins
RNA, Long Noncoding
X-chromosome inactivation
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Beschreibung
Zusammenfassung:Ribonucleoprotein complexes containing Xist, a long non-coding RNA involved in X chromosome inactivation, are immunogenic and promote autoimmune responses.
ISSN:1759-4790
1759-4804
DOI:10.1038/s41584-024-01101-z