Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual
To investigate the immunological consequences of hypervaccination in this unique situation, we submitted an analysis proposal to HIM via the public prosecutor. A reference cohort of 29 vaccinees (55% female, 45% male) with a three-dose mRNA regimen served as a control group.3 HIM's anti-spike I...
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| Veröffentlicht in: | The Lancet infectious diseases 2024-05, Vol.24 (5), p.e272-e274 |
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| container_title | The Lancet infectious diseases |
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| creator | Kocher, Katharina Moosmann, Carolin Drost, Felix Schülein, Christine Irrgang, Pascal Steininger, Philipp Zhong, Jahn Träger, Johannes Spriewald, Bernd Bock, Christoph Busch, Dirk H Bogdan, Christian Schubert, Benjamin Winkler, Thomas H Tenbusch, Matthias Schuster, Ev-Marie Schober, Kilian |
| description | To investigate the immunological consequences of hypervaccination in this unique situation, we submitted an analysis proposal to HIM via the public prosecutor. A reference cohort of 29 vaccinees (55% female, 45% male) with a three-dose mRNA regimen served as a control group.3 HIM's anti-spike IgG levels were highest on the day of the 214th vaccination and on day 3 after the 215th vaccination, but contraction kinetics subsequently mirrored those of the control group (figure B). [...]analysis of spike-reactive CD4+ T cells confirmed a lack of nucleocapsid-specific immunity and showed similar amounts of cytokine-producing CD4+ T cells in HIM compared with the control group, with preserved peptide sensitivity (appendix 2 p 15 G). |
| doi_str_mv | 10.1016/S1473-3099(24)00134-8 |
| format | Article |
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| subjects | Adaptive Immunity Antigens CD4 antigen COVID-19 - immunology COVID-19 - prevention & control COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology Cytokines Genotype & phenotype Humans Immunoglobulin G Immunology Lymphocytes Lymphocytes T mRNA Nucleocapsids Peptides Public prosecutors SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Vaccination |
| title | Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual |
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