Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual

To investigate the immunological consequences of hypervaccination in this unique situation, we submitted an analysis proposal to HIM via the public prosecutor. A reference cohort of 29 vaccinees (55% female, 45% male) with a three-dose mRNA regimen served as a control group.3 HIM's anti-spike IgG levels were highest on the day of the 214th vaccination and on day 3 after the 215th vaccination, but contraction kinetics subsequently mirrored those of the control group (figure B). [...]analysis of spike-reactive CD4+ T cells confirmed a lack of nucleocapsid-specific immunity and showed similar amounts of cytokine-producing CD4+ T cells in HIM compared with the control group, with preserved peptide sensitivity (appendix 2 p 15 G).