Biochemical and toxicological profiles of venoms from an adult female South American bushmaster (Lachesis muta rhombeata) and her offspring

In this work, we compared the biochemical and toxicological profiles of venoms from an adult female specimen of Lachesis muta rhombeata (South American bushmaster) and her seven offspring born in captivity, based on SDS-PAGE, RP-HPLC, enzymatic, coagulant, and hemorrhagic assays. Although adult and...

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Veröffentlicht in:	Toxicon (Oxford) 2024-04, Vol.241, p.107680-107680, Article 107680
Hauptverfasser:	Galizio, Nathália C., Moraes-Santos, Laura S., Yabunaka, Ana C., Demico, Poliana J., Torres-Bonilla, Kristian A., Varón, Julian C.G., Silva Jr, Nelson J.da, Tanaka-Azevedo, Anita M., Rocha, Marisa M.Teixeira da, Hyslop, Stephen, Floriano, Rafael S., Morais-Zani, Karen de
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antivenins - pharmacology Crotalid Venoms - chemistry Crotalid Venoms - toxicity Crotalinae Female Hemorrhage Humans Lachesis muta rhombeata Ontogenetic venom variability Thrombin Venom neutralization Venomous Snakes
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Zusammenfassung:	In this work, we compared the biochemical and toxicological profiles of venoms from an adult female specimen of Lachesis muta rhombeata (South American bushmaster) and her seven offspring born in captivity, based on SDS-PAGE, RP-HPLC, enzymatic, coagulant, and hemorrhagic assays. Although adult and juvenile venoms showed comparable SDS-PAGE profiles, juveniles lacked some chromatographic peaks compared with adult venom. Adult venom had higher proteolytic (caseinolytic) activity than juvenile venoms (p
ISSN:	0041-0101 1879-3150
DOI:	10.1016/j.toxicon.2024.107680