Preparation, fundamental characteristics and biosafety evolution of compound rhBMP-2/CPC

To study the fundamental characteristics and biosafety of the compound bone morphogenetic protein (BMP) and rhBMP-2/CPC, and to provide a theoretical basis for the compound biologically active artificial bone made of calcium phosphate cement (CPC) and bone morphogenetic protein, simplex CPC was taken as the control group, and the compound with the blending ratio of 1 g CPC to 5 mg rhBMP-2 was taken as the experimentation group to determine the setting time, compressive strength, acute toxicological and sub acute toxicological properties. The osteogenic characteristic of compound rhBMP-2/CPC was measured by making animal model of radio discontinuous defect. The setting time of the two groups meets the clinical requirements, and the compressive strength of the solidified body of bone cement increases along with increasing the immersion time. Compound rhBMP-2/CPC has a favorable osteogenic characteristic for animal model of radio discontinuous defect. The fundamental characteristics of the compound rhBMP-2 phosphate bone cement are basically the same as that of CPC, and also have a favorable biosafety and osteogenesis.