Investigating the interpretability of schizophrenia EEG mechanism through a 3DCNN-based hidden layer features aggregation framework

Electroencephalogram (EEG) signals record brain activity, with growing interest in quantifying neural activity through complexity analysis as a potential biological marker for schizophrenia. Presently, EEG complexity analysis primarily relies on manual feature extraction, which is subjective and yields varied findings in studies involving schizophrenia and healthy controls. This study aims to leverage deep learning methods for enhanced EEG complexity exploration, aiding early schizophrenia screening and diagnosis. Our proposed approach utilizes a three-dimensional Convolutional Neural Network (3DCNN) to extract enhanced data features for early schizophrenia identification and subsequent complexity analysis. Leveraging the spatiotemporal capabilities of 3DCNN, we extract advanced latent features and employ knowledge distillation to reintegrate these features into the original channels, creating feature-enhanced data. We employ a 10-fold cross-validation strategy, achieving the average accuracies of 99.46% and 98.06% in subject-dependent experiments on Dataset 1(14SZ and 14HC) and Dataset 2 (45SZ and 39HC). The average accuracy for subject-independent is 96.04% and 92.67% on both datasets. Feature extraction and classification are conducted on both the re-aggregated data and the original data. Our results demonstrate that re-aggregated data exhibit superior classification performance and a more stable training process after feature extraction. In the complexity analysis of re-aggregated data, we observe lower entropy features in schizophrenic patients compared to healthy controls, with more pronounced differences in the temporal and frontal lobes. Analyzing Katz's Fractal Dimension (KFD) across three sub-bands of lobe channels reveals the lowest α band KFD value in schizophrenia patients. This emphasizes the ability of our method to enhance the discrimination and interpretability in schizophrenia detection and analysis. Our approach enhances the potential for EEG-based schizophrenia diagnosis by leveraging deep learning, offering superior discrimination capabilities and richer interpretive insights. •Introduce a 3DCNN-based framework for enhanced EEG schizophrenia detection and analysis.•Re-aggregated EEG data by offers superior classification and interpretability.•Noted lower entropy features in schizophrenic EEG, especially in temporal/frontal lobes.•Demonstrated richer EEG interpretability linking brain lobes and functional differences.