Effect of Concomitant Drugs on Sodium Zirconium Cyclosilicate Hydrate in Artificial Intestinal Juice

To explore drug interactions involving sodium zirconium cyclosilicate hydrate (SZC) and concomitant drugs like calcium antagonists (amlodipine and nifedipine) and β-blockers (carvedilol and bisoprolol), we investigate how these concomitant drugs influenced the administration of SZC in an artificial...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2024/03/06, Vol.72(3), pp.286-293
Hauptverfasser:	Mizuno, Yuri, Ogata, Fumihiko, Uematsu, Yugo, Kawasaki, Naohito
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Antagonists Beta blockers Calcium calcium antagonist Calcium antagonists concomitant drug Drug interaction Drugs Hyperkalemia Intestine Ion adsorption Juices Nifedipine Polystyrene Polystyrene resins Potassium potassium ion Qualitative analysis Sodium Sodium polystyrene sulfonate sodium zirconium cyclosilicate hydrate Zirconium β-blocker drug
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Zusammenfassung:	To explore drug interactions involving sodium zirconium cyclosilicate hydrate (SZC) and concomitant drugs like calcium antagonists (amlodipine and nifedipine) and β-blockers (carvedilol and bisoprolol), we investigate how these concomitant drugs influenced the administration of SZC in an artificial intestinal juice. Initially, we assessed the potassium ion adsorption capacity, ranking it as follows: calcium polystyrene sulfonate (CPS, 54.9 mg/g)
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c23-00687