Injectable gel: Poly(ethylene glycol)–sebacic acid polyester
In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)–sebacic acid polyester was synthesized. The polymer aqueous solution (25 wt%) undergoes ‘...
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| Veröffentlicht in: | Polymer (Guilford) 2006-05, Vol.47 (11), p.3760-3766 |
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| container_end_page | 3766 |
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| container_issue | 11 |
| container_start_page | 3760 |
| container_title | Polymer (Guilford) |
| container_volume | 47 |
| creator | Lee, Jisun Joo, Min Kyung Oh, Hejin Sohn, Youn Soo Jeong, Byeongmoon |
| description | In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)–sebacic acid polyester was synthesized. The polymer aqueous solution (25
wt%) undergoes ‘clear sol-to-gel’ transition as the temperature increases from 5 to 65
°C. The drug can be mixed in a low viscous sol state at low temperature ( |
| doi_str_mv | 10.1016/j.polymer.2006.03.109 |
| format | Article |
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wt%) undergoes ‘clear sol-to-gel’ transition as the temperature increases from 5 to 65
°C. The drug can be mixed in a low viscous sol state at low temperature (<15
°C). In particular, the thermogel is soft enough to be injected through a 21-gauge syringe needle even as a gel state. The model hydrophilic drug, FITC–dextran (molecular weight: 40,000
Da), was released from the gel over 24
h. The biodegradable poly(ethylene glycol)–sebacic acid polyester soft thermogel is believed to be promising for the hydrophilic drug delivery where an initial burst of a drug might be a concern.</description><identifier>ISSN: 0032-3861</identifier><identifier>EISSN: 1873-2291</identifier><identifier>DOI: 10.1016/j.polymer.2006.03.109</identifier><identifier>CODEN: POLMAG</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Applied sciences ; Biodegradable polymer ; Biological and medical sciences ; Drug delivery ; Exact sciences and technology ; General pharmacology ; Medical sciences ; Organic polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Polymers with particular properties ; Preparation, kinetics, thermodynamics, mechanism and catalysts ; Sol–gel transition</subject><ispartof>Polymer (Guilford), 2006-05, Vol.47 (11), p.3760-3766</ispartof><rights>2006 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-7c989b1d64723d59698b6de9b22f22a4c27b4f6d85d58e6d138f991710640d13</citedby><cites>FETCH-LOGICAL-c401t-7c989b1d64723d59698b6de9b22f22a4c27b4f6d85d58e6d138f991710640d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.polymer.2006.03.109$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17811420$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jisun</creatorcontrib><creatorcontrib>Joo, Min Kyung</creatorcontrib><creatorcontrib>Oh, Hejin</creatorcontrib><creatorcontrib>Sohn, Youn Soo</creatorcontrib><creatorcontrib>Jeong, Byeongmoon</creatorcontrib><title>Injectable gel: Poly(ethylene glycol)–sebacic acid polyester</title><title>Polymer (Guilford)</title><description>In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)–sebacic acid polyester was synthesized. The polymer aqueous solution (25
wt%) undergoes ‘clear sol-to-gel’ transition as the temperature increases from 5 to 65
°C. The drug can be mixed in a low viscous sol state at low temperature (<15
°C). In particular, the thermogel is soft enough to be injected through a 21-gauge syringe needle even as a gel state. The model hydrophilic drug, FITC–dextran (molecular weight: 40,000
Da), was released from the gel over 24
h. The biodegradable poly(ethylene glycol)–sebacic acid polyester soft thermogel is believed to be promising for the hydrophilic drug delivery where an initial burst of a drug might be a concern.</description><subject>Applied sciences</subject><subject>Biodegradable polymer</subject><subject>Biological and medical sciences</subject><subject>Drug delivery</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Organic polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Polymers with particular properties</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><subject>Sol–gel transition</subject><issn>0032-3861</issn><issn>1873-2291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkM1KAzEUhYMoWKuPIHSj6GLqTSaTSVwoUvwpFHTRfcgkd3RKOlOTVujOd_ANfRJTWnDZTS45fOccOIScUxhSoOJmNlx0fj3HMGQAYgh5ktUB6VFZ5hljih6SHkDOslwKekxOYpwBACsY75G7cTtDuzSVx8E7-tvBW4q6wuXH2mObJL-2nb_-_f6JWBnb2EF63GDTh3GJ4ZQc1cZHPNvdPpk-PU5HL9nk9Xk8ephklgNdZqVVUlXUCV6y3BVKKFkJh6pirGbMcMvKitfCycIVEoWjuayVoiUFwSH9-uRyG7sI3ecqNet5Ey16b1rsVlEzxZNF5ntBqjgHWfIEFlvQhi7GgLVehGZuwlpT0JtV9UzvVtWbVTXkSVbJd7ErMNEaXwfT2ib-m0tJKWeQuPsth2mVryalRNtga9E1Ie2tXdfsafoDDCqP4g</recordid><startdate>20060517</startdate><enddate>20060517</enddate><creator>Lee, Jisun</creator><creator>Joo, Min Kyung</creator><creator>Oh, Hejin</creator><creator>Sohn, Youn Soo</creator><creator>Jeong, Byeongmoon</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>F28</scope><scope>JG9</scope></search><sort><creationdate>20060517</creationdate><title>Injectable gel: Poly(ethylene glycol)–sebacic acid polyester</title><author>Lee, Jisun ; Joo, Min Kyung ; Oh, Hejin ; Sohn, Youn Soo ; Jeong, Byeongmoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-7c989b1d64723d59698b6de9b22f22a4c27b4f6d85d58e6d138f991710640d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Applied sciences</topic><topic>Biodegradable polymer</topic><topic>Biological and medical sciences</topic><topic>Drug delivery</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Organic polymers</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Polymers with particular properties</topic><topic>Preparation, kinetics, thermodynamics, mechanism and catalysts</topic><topic>Sol–gel transition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jisun</creatorcontrib><creatorcontrib>Joo, Min Kyung</creatorcontrib><creatorcontrib>Oh, Hejin</creatorcontrib><creatorcontrib>Sohn, Youn Soo</creatorcontrib><creatorcontrib>Jeong, Byeongmoon</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><jtitle>Polymer (Guilford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jisun</au><au>Joo, Min Kyung</au><au>Oh, Hejin</au><au>Sohn, Youn Soo</au><au>Jeong, Byeongmoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Injectable gel: Poly(ethylene glycol)–sebacic acid polyester</atitle><jtitle>Polymer (Guilford)</jtitle><date>2006-05-17</date><risdate>2006</risdate><volume>47</volume><issue>11</issue><spage>3760</spage><epage>3766</epage><pages>3760-3766</pages><issn>0032-3861</issn><eissn>1873-2291</eissn><coden>POLMAG</coden><abstract>In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)–sebacic acid polyester was synthesized. The polymer aqueous solution (25
wt%) undergoes ‘clear sol-to-gel’ transition as the temperature increases from 5 to 65
°C. The drug can be mixed in a low viscous sol state at low temperature (<15
°C). In particular, the thermogel is soft enough to be injected through a 21-gauge syringe needle even as a gel state. The model hydrophilic drug, FITC–dextran (molecular weight: 40,000
Da), was released from the gel over 24
h. The biodegradable poly(ethylene glycol)–sebacic acid polyester soft thermogel is believed to be promising for the hydrophilic drug delivery where an initial burst of a drug might be a concern.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.polymer.2006.03.109</doi><tpages>7</tpages></addata></record> |
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| ispartof | Polymer (Guilford), 2006-05, Vol.47 (11), p.3760-3766 |
| issn | 0032-3861 1873-2291 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Applied sciences Biodegradable polymer Biological and medical sciences Drug delivery Exact sciences and technology General pharmacology Medical sciences Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts Sol–gel transition |
| title | Injectable gel: Poly(ethylene glycol)–sebacic acid polyester |
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