Injectable gel: Poly(ethylene glycol)–sebacic acid polyester

In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)–sebacic acid polyester was synthesized. The polymer aqueous solution (25 wt%) undergoes ‘...

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Veröffentlicht in:	Polymer (Guilford) 2006-05, Vol.47 (11), p.3760-3766
Hauptverfasser:	Lee, Jisun, Joo, Min Kyung, Oh, Hejin, Sohn, Youn Soo, Jeong, Byeongmoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Biodegradable polymer Biological and medical sciences Drug delivery Exact sciences and technology General pharmacology Medical sciences Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts Sol–gel transition
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Zusammenfassung:	In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)–sebacic acid polyester was synthesized. The polymer aqueous solution (25 wt%) undergoes ‘clear sol-to-gel’ transition as the temperature increases from 5 to 65 °C. The drug can be mixed in a low viscous sol state at low temperature (
ISSN:	0032-3861 1873-2291
DOI:	10.1016/j.polymer.2006.03.109