Metallothioneins Initiate Semiconducting Nanoparticle Cellular Toxicity
The toxicity of CdSe nanoparticles is mediated by metallothioneins (MTs), which are ubiquitous and cysteine‐rich. Surface Cd2+ ions are depleted from thiocarboxylate‐capped CdSe nanoparticles by recombinant MT‐based peptides (see figure), while surface Zn2+ ion depletion from ZnS‐coated CdSe nanopar...
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| Veröffentlicht in: | Small (Weinheim an der Bergstrasse, Germany) Germany), 2006-10, Vol.2 (10), p.1159-1163 |
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| container_title | Small (Weinheim an der Bergstrasse, Germany) |
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| creator | Aryal, Baikuntha P. Neupane, Kosh P. Sandros, Marinella G. Benson, David E. |
| description | The toxicity of CdSe nanoparticles is mediated by metallothioneins (MTs), which are ubiquitous and cysteine‐rich. Surface Cd2+ ions are depleted from thiocarboxylate‐capped CdSe nanoparticles by recombinant MT‐based peptides (see figure), while surface Zn2+ ion depletion from ZnS‐coated CdSe nanoparticles is more difficult. Due to the overall cellular expression and antioxidant roles for MT, a model for MT‐mediated CdSe nanoparticle toxicity is proposed. |
| doi_str_mv | 10.1002/smll.200500527 |
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Surface Cd2+ ions are depleted from thiocarboxylate‐capped CdSe nanoparticles by recombinant MT‐based peptides (see figure), while surface Zn2+ ion depletion from ZnS‐coated CdSe nanoparticles is more difficult. 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Due to the overall cellular expression and antioxidant roles for MT, a model for MT‐mediated CdSe nanoparticle toxicity is proposed.</description><subject>Cadmium Compounds</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Free Radicals</subject><subject>Mass Spectrometry - methods</subject><subject>Metallothionein - chemistry</subject><subject>Metallothionein - physiology</subject><subject>nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanostructures - chemistry</subject><subject>Nanotechnology - instrumentation</subject><subject>Nanotechnology - methods</subject><subject>Nitric Oxide - chemistry</subject><subject>Peptides - chemistry</subject><subject>proteins</subject><subject>Proteins - chemistry</subject><subject>radicals</subject><subject>Reactive Oxygen Species</subject><subject>Selenium Compounds</subject><subject>Semiconductors</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Sulfides - chemistry</subject><subject>toxicity</subject><subject>Zinc Compounds - chemistry</subject><issn>1613-6810</issn><issn>1613-6829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EolBYGVEmtpTzV5yMUEFBSsvQIkbLdRwwOEmJHUH_PalaFTakk-6G5311ehC6wDDCAOTaV86NCADvh4gDdIITTOMkJdnh_sYwQKfevwNQTJg4RgMscEZ5Sk7QZGqCcq4Jb7apja199FjbYFUw0dxUVjd10elg69dopupmpdpgtTPR2DjXOdVGi-bbahvWZ-ioVM6b890eouf7u8X4Ic6fJo_jmzzWrP8vpgVnlBBBKUC6FEm2JAobwUFBplnCE9A81aWmCTbpkmHAtGDEpGUBXJQkpUN0te1dtc1nZ3yQlfW6_0bVpum8JBmDjNCkB0dbULeN960p5aq1lWrXEoPcqJMbdXKvrg9c7pq7ZWWKX3znqgeyLfBlnVn_Uyfn0zz_Wx5vs9YH873PqvZDJoIKLl9mE8l4zsa3LJML-gNASIma</recordid><startdate>200610</startdate><enddate>200610</enddate><creator>Aryal, Baikuntha P.</creator><creator>Neupane, Kosh P.</creator><creator>Sandros, Marinella G.</creator><creator>Benson, David E.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>200610</creationdate><title>Metallothioneins Initiate Semiconducting Nanoparticle Cellular Toxicity</title><author>Aryal, Baikuntha P. ; 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Cadmium Compounds Electron Spin Resonance Spectroscopy Free Radicals Mass Spectrometry - methods Metallothionein - chemistry Metallothionein - physiology nanoparticles Nanoparticles - chemistry Nanostructures - chemistry Nanotechnology - instrumentation Nanotechnology - methods Nitric Oxide - chemistry Peptides - chemistry proteins Proteins - chemistry radicals Reactive Oxygen Species Selenium Compounds Semiconductors Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Sulfides - chemistry toxicity Zinc Compounds - chemistry |
| title | Metallothioneins Initiate Semiconducting Nanoparticle Cellular Toxicity |
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