Metallothioneins Initiate Semiconducting Nanoparticle Cellular Toxicity

The toxicity of CdSe nanoparticles is mediated by metallothioneins (MTs), which are ubiquitous and cysteine‐rich. Surface Cd2+ ions are depleted from thiocarboxylate‐capped CdSe nanoparticles by recombinant MT‐based peptides (see figure), while surface Zn2+ ion depletion from ZnS‐coated CdSe nanopar...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2006-10, Vol.2 (10), p.1159-1163
Hauptverfasser:	Aryal, Baikuntha P., Neupane, Kosh P., Sandros, Marinella G., Benson, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cadmium Compounds Electron Spin Resonance Spectroscopy Free Radicals Mass Spectrometry - methods Metallothionein - chemistry Metallothionein - physiology nanoparticles Nanoparticles - chemistry Nanostructures - chemistry Nanotechnology - instrumentation Nanotechnology - methods Nitric Oxide - chemistry Peptides - chemistry proteins Proteins - chemistry radicals Reactive Oxygen Species Selenium Compounds Semiconductors Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Sulfides - chemistry toxicity Zinc Compounds - chemistry
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Beschreibung
Zusammenfassung:	The toxicity of CdSe nanoparticles is mediated by metallothioneins (MTs), which are ubiquitous and cysteine‐rich. Surface Cd2+ ions are depleted from thiocarboxylate‐capped CdSe nanoparticles by recombinant MT‐based peptides (see figure), while surface Zn2+ ion depletion from ZnS‐coated CdSe nanoparticles is more difficult. Due to the overall cellular expression and antioxidant roles for MT, a model for MT‐mediated CdSe nanoparticle toxicity is proposed.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.200500527