Prognostic implications of tumor-infiltrating lymphocytes within the tumor microenvironment in gastric cancer

Tumor-infiltrating lymphocytes (TILs) play a regulatory role in the tumor-associated immune response and are important in the prognosis and treatment response of several cancers. However, because of its heterogeneity, the prognostic value of TILs in gastric cancer (GC) is still controversial. Thus,...

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Veröffentlicht in:Journal of gastrointestinal surgery 2024-02, Vol.28 (2), p.151-157
Hauptverfasser: Pereira, Marina Alessandra, Ramos, Marcus Fernando Kodama Pertille, Cardili, Leonardo, de Moraes, Rafael Dyer Rodrigues, Dias, André Roncon, Szor, Daniel Jose, Zilberstein, Bruno, Alves, Venancio Avancini Ferreira, de Mello, Evandro Sobroza, Ribeiro, Ulysses
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Sprache:eng
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Zusammenfassung:Tumor-infiltrating lymphocytes (TILs) play a regulatory role in the tumor-associated immune response and are important in the prognosis and treatment response of several cancers. However, because of its heterogeneity, the prognostic value of TILs in gastric cancer (GC) is still controversial. Thus, this study aimed to investigate the association between the density of TILs and patients’ outcomes in GC. Patients with gastric adenocarcinoma who underwent curative intent gastrectomy were retrospectively investigated. The groups for analysis were determined on the basis of TIL intensity and percentage of CD3+ T-cell infiltration by immunohistochemical. Furthermore, Epstein-Barr virus (EBV), microsatellite instability (MSI), T-cell ratio of CD4 to CD8, and programmed death protein ligand 1 (PD-L1) status were evaluated. A total of 345 patients were enrolled: 124 patients with GCs (35.9%) were classified as the low-CD3+ TIL group, and 221 patients with GCs (64.1%) were classified as the high-CD3+ TIL group. Poorly differentiated histology (P = .014), EBV-positive status (P 
ISSN:1091-255X
1873-4626
DOI:10.1016/j.gassur.2023.12.002