The anti-apoptotic role of Ginkgolide B via mitochondrial permeability transition pore inhibition in retinal ischemia-reperfusion

This research delves into the effectiveness of Ginkgolide B (GB), a compound from Ginkgo biloba, in combating cell death caused by glaucoma, with a focus on mitochondrial impairment and the mitochondrial permeability transition pore (mPTP). Utilizing models of high intraocular pressure and in vitro...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-04, Vol.705, p.149722, Article 149722
Hauptverfasser:	Wang, Xiou, Hu, Baoqi, Zhang, Hanyue, Zhou, Sijia, Wu, Wenfei, Tan, Zizhu, Sun, Meiqi, Kang, Qianyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis calcium Ginkgo biloba Ginkgolide B Ginkgolides - pharmacology Glaucoma Glucose Lactones - pharmacology membrane potential mitochondria Mitochondrial function Mitochondrial Permeability Transition Pore mPTP nerve fibers OGD/R Oxygen permeability protective effect Rats Retina nerve fiber layer Retinal pregenital cells therapeutics Western blotting
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