Ruxolitinib Pharmacokinetics and Pharmacodynamics in Children with Acute and Chronic Graft-versus-Host Disease

We evaluated the pharmacokinetics (PK) of oral ruxolitinib in children with steroid-refractory acute graft-versus-host disease (aGVHD) (age 10 kg and before, 3+, and 6+ hours in children weighing

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Bibliographische Detailangaben
Veröffentlicht in:	Transplantation and cellular therapy 2024-05, Vol.30 (5), p.528.e1-528.e12
Hauptverfasser:	Cook, Eleanor, Dong, Min, Chiang, Samuel C.C., Luedeke, David, Lake, Kelly E., Hoerth, Colin, Deavy, Marisa, Setchell, Kenneth D.R., Zhao, Junfang, Punt, Nieko, Galletta, Thomas, Teusink-Cross, Ashley, Davies, Stella M., Marsh, Rebecca A., Mehta, Parinda, Khandelwal, Pooja
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Child Child, Preschool Chronic Disease Female Graft vs Host Disease - drug therapy Hematopoietic Stem Cell Transplantation Humans Infant Male Nitriles Pediatric ruxolitinib Prospective Studies Pyrazoles - pharmacokinetics Pyrazoles - therapeutic use Pyrimidines - pharmacokinetics Pyrimidines - therapeutic use Ruxolitinib Ruxolitinib for GVHD STAT1 Transcription Factor - metabolism STAT3 Transcription Factor - metabolism STAT5 Transcription Factor - metabolism
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Beschreibung
Zusammenfassung:	We evaluated the pharmacokinetics (PK) of oral ruxolitinib in children with steroid-refractory acute graft-versus-host disease (aGVHD) (age 10 kg and before, 3+, and 6+ hours in children weighing
ISSN:	2666-6367 2666-6367
DOI:	10.1016/j.jtct.2024.02.018