The role of ncRNAs‐mediated pyroptosis in diabetes and its vascular complications

Over the past decade, the prevalence of diabetes has increased significantly worldwide, leading to an increase in vascular complications of diabetes (VCD), such as diabetic cardiomyopathy (DCM), diabetic nephropathy (DN), and diabetic retinopathy (DR). Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), long Noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), play a key role in cellular processes, including the pathophysiology of diabetes and VCD via pyroptosis. ncRNAs (e.g., miR‐17, lnc‐MEG3, and lnc‐KCNQ1OT1) can regulate pyroptosis in pancreatic β cells. Some ncRNAs are involved in VCD progression. For example, miR‐21, lnc‐KCNQ1OT1, lnc‐GAS5, and lnc‐MALAT1 were reported in DN and DCM, and lnc‐MIAT was identified in DCM and DR. Herein, this review aimed to summarize recent research findings related to ncRNAs‐mediated pyroptosis at the onset and progression of diabetes and VCD. Significance statement Metabolic disease, such as diabetes, have seriously caused economic and social burden. The role of noncoding RNAs (ncRNAs) in diabetes and its vascular complications has been widely concerned. ncRNAs is a new discovery in the field of pyroptosis, which may provide a new idea for the regulation of VCD. There are many tandem parts in the regulation process of ncRNAs and pyroptosis. This paper summarized the involvement of ncRNAs including microRNAs, long Noncoding RNAs, and circular RNAs in mediating pyroptosis, an inflammatory form of programmed cell death, in diabetes and diabetic vascular complications.