PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection

Protein arginine methyltransferases (PRMTs) modify diverse protein targets and regulate numerous cellular processes; yet, their contributions to individual effector T cell responses during infections are incompletely understood. In this study, we identify PRMT5 as a critical regulator of CD4+ T foll...

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Veröffentlicht in:The Journal of immunology (1950) 2024-05, Vol.212 (9), p.1442-1449
Hauptverfasser: Read, Kaitlin A, Amici, Stephanie A, Farsi, Sadaf, Cutcliffe, Madeline, Lee, Bella, Lio, Chan-Wang Jerry, Wu, Hsin-Jung Joyce, Guerau-de-Arellano, Mireia, Oestreich, Kenneth J
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Sprache:eng
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Zusammenfassung:Protein arginine methyltransferases (PRMTs) modify diverse protein targets and regulate numerous cellular processes; yet, their contributions to individual effector T cell responses during infections are incompletely understood. In this study, we identify PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in an almost complete ablation of both Tfh and T follicular regulatory populations and, consequently, reduced B cell activation and influenza-specific Ab production. Supporting a potential mechanism, we observe elevated surface expression of IL-2Rα on non-T regulatory effector PRMT5-deficient T cells. Notably, IL-2 signaling is known to negatively impact Tfh differentiation. Collectively, our findings identify PRMT5 as a prominent regulator of Tfh programming, with potential causal links to IL-2 signaling.
ISSN:0022-1767
1550-6606
1550-6606
DOI:10.4049/jimmunol.2300270